Research
|
|
Autoimmune diseases include different syndromes of mostly unknown causes.
|
|
|
Cancer treatment is undergoing a biomedical and technological revolution.
|
|
|
Intestinal inflammation is the central feature of the Inflammatory Bowel Diseases.
|
|
|
Diabetes is linked to either the failure or destruction of pancreatic beta cells.
|
|
|
Sepsis is an increasingly frequent and lethal syndrome resulting from bloodstream infections.
|
People
 |
Dr. Jamey Marth, Ph.D.
Professor and Director
Immunity and Pathogeneiss Program
Infectious and Inflammatory Diseases Center
SBP Medical
Discovery Institute
jmarth@sbpdiscovery.org
|
Administrative Personnel
Research Team at Sanford Burnham Prebys and other affiliated Institutes
 |
Peter Aziz, M.Sc.
Research Specialist & Lab Manager
SBP Medical Discovery Institute
|
 |
Jeffrey Esko, Ph.D.
Co-Director, Glycobiology Research & Training Center
Distinguished Professor, Department of Cellular & Molecular Medicine
UC San Diego
|
 |
Jeffrey Fried, M.D.
Acute Care Physician
Associate Program Director of the Internal Medicine Residency
Director of Critical Care Education and Research
Cottage Hospital Santa Barbara
|
 |
Douglas Heithoff, Ph.D.
Project Scientist
UC Santa Barbara
|
 |
John Hintze, Ph.D.
Postdocotral Research Scientist
SBP Medical Discovery Institute
|
 |
Dzung Le, M.D., Ph.D.
Clinical Professor and Director
UC San Diego
|
 |
Michael J. Mahan, Ph.D.
Professor
Molecular, Cellular, and Developmental Biology
UC Santa Barbara
|
 |
Victor Nizet, M.D.
Professor & Vice Chair for Basic Research, Department of Pediatrics, UCSD
Chief, Division of Host-Microbe Systems & Therapeutics
Professor, Skaggs School of Pharmacy & Pharmaceutical Sciences
|
 |
Kathryn Smith, B.Sc.
Research Technician
SBP Medical Discovery Institute
|
 |
Gabriel Wardi, M.D.
Assistant Professor, Emergency Medicine
UC San Diego
|
 |
Won Ho Yang, Ph.D.
Assistant Professor, Yonsei University
Senior Research Associate
SBP Medical Research Institute
|
 |
Mayank Saraswat, Ph.D.
Sr. Staff Scientist
SBP Medical Discovery Institute
|
 |
Robert Fraumeni, B.Sc.
Research Assistant II
SBP Medical Discovery Institute
|
 |
Don Clarke, Ph.D.
Medical Research Scientist
SBP Medical Discovery Institute
|
 |
Thomas Strong, Ph.D.
Medical Research Scientist
SBP Medical Discovery Institute
|
Selected Publications
Yang, W.H., Westman, J.S., Heithoff, D.M., Sperandio, M., Cho, J.W., Mahan, M.J., and Marth, J.D. (2021)
Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food poisoning.
Proc. Natl. Acad. Sci. USA, 118, doi: 10.1073/pnas.2100937118.
Yang, W.H., Heithoff, D.M., Aziz, P.V., Haslund-Gourley, B., Westman, J.S., Narisawa, S., Pinkerton, A.B., Millan, J.L., Nizet, V., Mahan, M.J., and Marth, J.D. (2018).
Accelerated aging and clearance of host anti-inflammatory enzymes by a subset of pathogens fuels sepsis.
Cell Host & Microbe 24, 500-513.
Yang, W.H., Heithoff, D.M., Aziz, P.V., Sperandio, M., Nizet, V., Mahan, M.J., and Marth, J.D. (2017).
Recurrent infection disables host protection against intestinal inflammation.
Science, 358, doi: 10.1126/science.aao5610.
Yang, W.H., Aziz, P.V., Heithoff, D.M., Mahan, M.J., Smith, J.W., and Marth, J.D. (2015).
An intrinsic mechanism of secreted protein aging and turnover.
Proc. Natl. Acad. Sci. USA 112, 13657-13662.
Grewal, P.K., Aziz, P.V., Uchiyama, S., Rubio, G.R., Lardone, R.D., Le, D, Varki, N., Nizet, V., and Marth, J.D. (2013).
Inducing host protection in pneumococcal sepsis by pre-activation of the Ashwell-Morell receptor.
Proc. Natl. Acad. Sci. USA 17, 110, 20218-20223.
Ohtsubo, K., Chen, M.Z., Olefsky, J.M., and Marth, J.D. (2011).
Pathway to diet- and obesity-associated diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport.
Nat. Med., 17, 1067-1075.
Grewal, P.K., Uchiyama, S., Ditto, D., Varki, N., Le, D.T., Nizet, V., and Marth, J.D. (2008).
N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis.
Nat. Med., 14, 648-655.
Green, R.S., Stone, E.L. Tenno, M., Lehtonen, E., Farquhar, M.G., and Marth, J.D. (2007).
N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis.
Immunity 27, 308-320.
Ohtsubo, K., Takamatsu, S., Minowa, M.T., Yoshida, A., Takeuchi, M., and Marth, J.D. (2005).
Dietary and genetic control of glucose transporter-2 glycosylation promotes insulin secretion in suppressing diabetes.
Cell 123, 1307-1321.
Chui, D., Sellakumar, G., Green, R.S., Sutton-Smith, M., McQuistan, T., Marek, K.W., Morris, H.R., Dell, A., and Marth, J.D. (2001).
Genetic re-modeling of protein glycosylation in vivo induces autoimmune disease.
Proc. Natl. Acad. Sci. USA 98, 1142-1147.
Ellies, L.G., Tsuboi, S., Petryniak, B., Lowe, J.B., Fukuda, M., and Marth, J.D. (1998).
Core 2 O-glycan biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation.
Immunity 9, 881-890.
All Marth Lab Publications
Employment
Interested, qualified applicants for Research Technicians, Postdoctoral Associates, and Medical Research positions should email their resumé or Curriculum Vitae including names and contacts for up to three references to
Araceli Ambert, aambert@sbpdiscovery.org.
|