Randal Kaufman Search

Randal Kaufman Papers - PubMed

 

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 Recent Publications

CNS axon protection and rescue of function by neuronal ER stress manipulation.
Yang, L., Li, S., Miao, L., Huang, H., Liang, F., Teng, X., Xu, L., Wang, Q., Xiao, X., Ridder III, W., Ferguson, T., Chen, D.F., Kaufman, R.J., Hu, Y., (2016)
J. Neuroscience. (In Press).
 
The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation.
Ravindran, R., Loebbermann, J., Nakaya, H.I., Khan, N., Ma, H., Gama, L., Machiah, D.K., Lawson, B., Hakimpour, P., Wang, Y., Li, S., Sharma, P., Kaufman, R.J., Martinez, J., Pulendran, B. (2016).
Nature 531(7595):523-7.
 
Read-Split-Run: An improved bioinformatics pipeline for identification of genome-wide non-canonical spliced regions using RNA-Seq data.
Bai, Y., Kinne, J., Donham, B., Jiang, F., Ding, L., Hassler, J.R., Kaufman, R.J. (2016)
BMC Genomics (In Press).
 
Borrelidin induces the unfolded protein response in oral cancer cells and Chop-dependent apoptosis.
Sidhu, A., Miller, J., Tripathi, A., Garshott, D., Brownell, A., Chiego, D., Arevang, C-J., Zeng, Q., Jackson, L., Bechler, S., Callaghan, M., Yoo, G., Sethi, S., Lin, H-S., Callaghan, J., Tamayo-Castillo, G., Sherman, D.^, Kaufman, R.J.^, Fribley, A^. (2015)
ACS Medicinal Chem. Letters 6(11):1122-1127. ^ Corresponding authors.
 
eIF2α confers cellular tolerance to S. aureus α-toxin.
Von Hoven, G., Neukirch, C., Meyenburg, M., Füser, S., Petrivna, M.B., Rivas, A.J., Ryazanov, A., Kaufman, R.J., Aroian, R.V., Husmann, M. (2015)
Front Immunol. 6:383. PMC451560.
 
Novel lobophorins inhibit oral cancer cell growth and Induce Atf4 and Chop-dependent cell death in murine fbroblasts.
Cruz, P.G., Fribley, A.F.^, Miller. J.R. Larsen, M.J., Schultz, P.J., Jacob, R.R.. Tamayo-Castillo, G., Kaufman, R.J.^, Sherman, D.H.^ (2015)
ACS Medicinal Chem. Letters. 6(8):877-881. PMID:26288688. ^ Corresponding authors.
 
The IRE1α/XBP1s pathway is essential for the glucose response and protection of β cells.
Hassler, J.H. Scheuner, D.L., Wang, S., Han, J.S., Kodali, V.K., Li, P., Nguyen, J., George, J.S., Davis, C., Wu, S.P., Sartor, M., Bai, Y., Cavalcoli, J., Malhi, H., Baudouin, G., Zhang, Y., Yates 3rd, J.R., Itkin-Ansari, P., Volkmann, N., Kaufman, R.J. (2015)
PLOS Biol. 13(10):e1002277. Commentary PLOS Biol. 2015 13(10): e1002278. PMC4607427.
 
Transcription factor ATF4 induces NLRP1 inflammasome expression during endoplasmic reticulum stress.
D’Osualdo, A., Anania, V.G., Yu, K., Lill, J.R., Kaufman, R.J., Matsuzawa, S-I., Reed, J.C. (2015)
PLOS One 10(6):e0130635. PMC4472728.
 
Mutations in the unfolded protein response regulator, ATF6, cause the cone dysfunction syndrome Achromatopsia.
Kohl, S., Zobor, D., Chiang, W-C. J., Weisschuh, N., Staller, Menendez, I.G., Chang, S., C. Beck, S.C., Garrido, M.G., Sothilingam, V., Seeliger, M.W., Stanzial, F., Benedicenti, F., Inzana, F., Heon, E., Vincent, A., Beis, J., Strom, T., Rudolph, G., Roosing, S., den Hollander, A., Cremers, F.P.M., Lopez, I., Ren, H., Moore, A., Webster, A., Michaelides, M., Koenekoop, R.K., Zrenner, E., Kaufman, R.J., Tsang, T.S., Wissinger, B., Lin, J. (2015)
Nature Genetics 47(7):757-65. PMC4610820.
 
C/EBP-homologous protein (CHOP) in vascular smooth muscle cells regulates their proliferation in aortic explants and atherosclerotic lesions.
Zhou, A-X., Wang, X., Lin, C.S., Han, J., Yong, J., Nadolski, M.J., Borén, J., Kaufman, R.J., Tabas, I. (2015)
Circulation Research 116(11):1736-43.
 
REVIEWS:
ER stress in disease.
Kaufman, R.J., Popolo, L. (2016)
In Encyclopedia of Cell Biology, Vol. 2, edited by Ralph A. Bradshaw and Philip D. Stahl. Academic Press. pp. 528-538.
 
Protein misfolding in the ER as a conduit to human disease.
Miao, M, Kaufman, R.J. (2016)
Nature 529(7586): 326-35.
 
When less is better: ER stress and beta cell proliferation.
Yong, J., Itkin-Ansari, P., Kaufman, R.J.(2016)
Dev. Cell. 36(1): 4-6.
 
Adaptive preconditioning in Neurological Diseases – Therapeutic Insights from Proteostatic Perturbations.
Mollereau, B., Rzechorzek, N.M., Roussel, B.D., Sedru, M., Van den Brink, D., Bailly-Maitre, B., Palladino, F., Medinas, D.B., Domingos, P.M., Hunot, S., Chandran, S., Birman, S., Baron, T., Vivien, D., Duarte, C.B., Ryoo, H.D., Steller. H., Urano, F., Chevet, E., Kroemer, G., Ciechanover, A., Calabrese, E.J., Kaufman, R.J., Hetz, C. (2016)
Brain Res. (In Press).
 
The unfolded protein response in immunity and inflammation.
Grootjans, J., Kaser, A., Kaufman. R.J.^, Blumberg, R.S.^ (2016)
Nature Reviews Immunology (In Press). ^ Corresponding authors.

 Noted Publications

Han J, Song B, Kim J, Kodali VK, Pottekat A, Wang M, Hassler J, Wang S, Pennathur S, Back SH, Katze MG, Kaufman RJ.
Diabetes. 2015 Mar 20. pii: db141357.
 
Wang S, Park S, Kodali VK, Han J, Yip T, Chen Z, Davidson NO, Kaufman RJ.
Mol Biol Cell. 2015 Feb 15;26(4):594-604. doi: 10.1091/mbc.E14-08-1274. Epub 2014 Dec 17
 
 
Wang M, Kaufman RJ.
Nat Rev Cancer. 2014 Sep;14(9):581-97. doi: 10.1038/nrc3800. Review.
PMID:
25145482
 
 
Cao SS, Kaufman RJ.
Antioxid Redox Signal. 2014 Jul 20;21(3):396-413. doi: 10.1089/ars.2014.5851. Epub 2014 Jun 12. Review
 
 
Ferris SP, Kodali VK, Kaufman RJ.
Dis Model Mech. 2014 Mar;7(3):331-41. doi: 10.1242/dmm.014589. Review
 
Cao SS, Wang M, Harrington JC, Chuang BM, Eckmann L, Kaufman RJ.
Inflamm Bowel Dis. 2014 Apr;20(4):712-22
 
Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M, Kilberg MS, Sartor MA, Kaufman RJ.
Nat Cell Biol. 2013 May;15(5):481-90
 
 
Wang S, Kaufman RJ.
Curr Opin Lipidol. 2014 Apr;25(2):125-32.
 
 
Han J, Kaufman RJ Methods Enzymol. 2014;538:135-50.
 
Sakaki K, Kaufman RJ.
Worm. 2013 Apr 1;2(2):e23005.
 
Ferris SP, Jaber NS, Molinari M, Arvan P, Kaufman RJ 
 
Landau G, Kodali VK, Malhotra JD, Kaufman RJ.
Methods Enzymol. 2013;526:231-50.
 
 
Cao SS, Zimmermann EM, Chuang BM, Song B, Nwokoye A, Wilkinson JE, Eaton KA, Kaufman RJ.
Gastroenterology. 2013 May;144(5):989-1000.e6. doi: 10.1053/j.gastro.2013.01.023. Epub 2013 Jan 18
 
 
Han J, Murthy R, Wood B, Song B, Wang S, Sun B, Malhi H, Kaufman RJ.
Diabetologia. 2013 Apr;56(4):911-24. doi: 10.1007/s00125-012-2809-
 
 
Wang S, Chen Z, Lam V, Han J, Hassler J, Finck BN, Davidson NO, Kaufman RJ.
Cell Metab. 2012 Oct 3;16(4):473-86
 
Cao SS, Kaufman RJ.
Curr Biol. 2012 Aug 21;22(16):R622-6.
 
Wang S, Kaufman RJ.
J Cell Biol. 2012 Jun 25;197(7):857-67