Ahn B, Soundarapandian MM, Sessions H, Peddibholta S, Roth G, Li J-L, Sugarman E, Koo A, Malany S, Wang M, Yea K, Brooks J, Leone TC, Han X, Vega RB, Kelly DP: MondoA links skeletal myocyte lipid homeostasis to insulin signaling. J Clin Invest, In press.

Horton JL, Martin OJ, Lai L, Riley NM, Richards AL, Vega RB, Leone TC, Pagliarini DJ, Muoio DM, Bedi Jr KC, Margulies KB, Coon JJ, Kelly DP: Mitochondrial protein hyperacetylation in the failing heart. JCI Insight. 2016; 1(2):e84897. PMCID: PMC4795836

Aubert G, Martin OJ, Horton JL, Lai L, Vega RB, Leone TC, Koves T, Gardell SJ, Kruger M, Lewandowski ED, Crawford PA, Muoio DM, Kelly DP: The failing heart relies on ketone bodies as a fuel. Circulation. 2016; Feb 23;133(8):698-705. PMCID: PMC4766035

Editorial Comment. Kolwicz Jr SC, Airhart S, Tian R: "Ketones step to the plate: A game changer for metabolic remodeling in heart failure?" Circulation. 2016; Feb 23;133(8):689-691.

Research Highlight. Huynh K: "Ketone bodies as fuel in heart failure." Nat Rev Cardiol. 2016; Mar;13(3):122-123.

Work highlighted in "Doctor Radio", SiriusXM Satellite Radio, Topic: Heart Failure Research. February 3, 2016.

Gong G, Song M, Csordas G, Kelly DP, Matkovich SJ, Dorn GW II: Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science. 2015; Dec 4;350(6265):aad2459. PMCID: PMC4747105

Editorial Comment. Gottlieb RA and Bernstein D: "Mitochondria shape cardiac metabolism." Science. 2015; Dec 4;350(6265):1162-1163.

Dorn GW II, Vega RB, Kelly DP: Mitochondrial biogenesis and dynamics in the developing and diseased heart. Genes Dev. 2015; Oct 1;29(19):1981-1991. PMCID: PMC4604339

Liao X, Zhang R, Lu Y, Prosdocimo DA, Sangwung P, Zhang L, Zhou G, Anand P, Lai L, Leone TC, Fujioka H, Ye F, Rosca MG, Hoppel CL, Schulze PC, Abel ED, Stamler JS, Kelly DP, Jain MK: Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. J Clin Invest. 2015; Sep 1;125(9):3461-3476. PMCID: PMC4588311

Ping P, Gustafsson A, Bers D, Blatter L, Cai HL, Jahangir A, Kelly DP, Muoio D, O'Rourke B, Rabinovitch P, Trayanova N, Van Eyk J, Weiss JN, Wong R, Longacre LS: Harnessing the power of integrated mitochondrial biology and physiology: A special report on the NHLBI mitochondria in heart disease initiative. Circ Res. 2015; Jul 17;117(3):234-238. PMCID: PMC4535701

Hershberger PM, Sugarman E, Maloney P, Peddibhotla S, Koo A, Suyama E, Ruidiaz ME, Heynen-Genel S, Nguyen KH, Vasile S, Mangravita-Novo A, Smith LH, Soundarapandian MM, Salaniwal S, Kung P, Vega RB, Chung TDY, Pinkerton AB, Malany S, Kelly DP: Inhibitors of myocyte triacylglyceride accumulation. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010. 2013; Dec 15 [updated 2015; Feb 11].

Ciron C, Zheng L, Bobela W, Knott GW, Leone TC, Kelly DP, Schneider BL: PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein. Acta Neuropathol Commun. 2015; Apr 1;3(1):16. PMCID: PMC4379693

Vega RB, Horton JL, Kelly DP: Maintaining ancient organelles: Mitochondrial biogenesis and maturation. Circ Res. 2015; 116:1820-1834. PMCID: PMC4443496

Weinheimer CJ, Lai L, Kelly DP, Kovacs A: A novel mouse model of left ventricular pressure overload and infarction causing predictable ventricular remodelling and progression to heart failure. Clin Exp Pharmacol Physiol. 2015; 42(1):33-40. PMCID: PMC4524882

Vega RB, Leone TC, Kelly DP: Transcriptional control of mitochondrial biogenesis and maturation. In: Cardiac Energy Metabolism in Health and Disease. Series: Advances in Biochemistry in Health and Disease, Vol. 11. Gary D. Lopaschuk and Naranjan S. Dhalla, editors. New York: Springer Media 2014; 89-102.

Theodosakis N, Micevic G, Kelly DP, Bosenberg M: Mitochondrial function in melanoma. Arch Biochem Biophys. 2014; Dec 1;563C:56-59.

Lai L, Leone TC, Keller MP, Martin OJ, Broman AT, Nigro J, Kapoor K, Koves TR, Stevens R, Ilkayeva OR, Vega RB, Attie AD, Muoio DM, Kelly DP: Energy metabolic re-programming in the hypertrophied and early stage failing heart: A multi-systems approach. Circ Heart Fail. 2014; 7(6):1022-1031. PMCID: PMC4241130

Editorial Comment. Hill BG, Schulze PC. "Insights into metabolic remodeling of the hypertrophic and failing myocardium". Circ Heart Fail. 2014; 7(6):874-876. PMCID: PMC4279713

Din S, Konstandin MH, Johnson B, Emanthinger J, Voelkers M, Toko H, Collins B, Ormachea L, Samse K, Kubli DA, De La Torre A, Kraft AS, Gustafsson AB, Kelly DP, Sussman MA: Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases. Circ Res. 2014; 115(3):376-387. PMCID: PMC4254755

Martin OJ, Lai L, Soundarapandian MM, Leone TC, Zorzano A, Keller MP, Attie AD, Muoio DM, Kelly DP: A role for peroxisome proliferator-activated receptor γ coactivator in the control of mitochondrial dynamics during postnatal cardiac growth. Circ Res. 2014; 114:626-636. PMCID: PMC4061768

Lai L, Wang M, Martin OJ, Leone TC, Vega RB, Han X, Kelly DP: A role for peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) in the regulation of cardiac mitochondrial phospholipid biosynthesis. J Biol Chem. 2014; 289:2250-2259. PMCID: PMC3900969 (“Paper of the Week”)

Sugarman E, Koo A, Suyama E, Ruidiaz M, Heynen-Genel S, Nguyen KH, Vasile S, Soundarapandian MM, Vega RB, Kelly DP, Smith LH, Malany S: Identification of inhibitors of triacylglyceride accumulation in muscle cells: Comparing HTS results from 1536-well plate-based and high content platforms. J Biomol Screen. 2014; 19(1):77-87. PMCID: PMC3901053 

Press Release of Gan et al, JCI  2013.

Gan Z, Rumsey J, Hazen BC, Lai L, Leone TC, Vega RB, Xie H, Conley KE, Auwerx J, Smith SR, Olson EN, Kralli A, Kelly DP: Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. J Clin Invest. 2013; Jun 3;123(6):2564-2575. PMCID: PMC3668841

Aubert G, Vega RB, Kelly DP:  Pertubations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart. Biochim Biophys Acta. 2013; Apr; 1833(4):840-847. PMCID: PMC3570640

Scarpulla RC, Vega RB, Kelly DP: Transcriptional integration of mitochondrial biogenesis.Trends Endocrinol Metab. 2012 Sep; 23:459-466. PMCID: PMC3580164

Kelly DP: Irisin, light my fire. Science. 2012 Apr 6; 336(6077):42-43. (Invited article)

Shi J, Jiang B, Qiu Y, Guan J, Jain M, Cao X, Bauer M, Su L, Burkly LC, Leone TC, Kelly DP, Liao R: PGC1α plays a critical role in TWEAK-induced cardiac dysfunction. PLoS ONE. 2013;8(1):e54054. PMCID: PMC3546975

Kim C, Wen J, Wong J, Wang S, Wang C, Spiering S, Kan NG, Forcales S, Puri PL, Leone TC, Marine JE, Calkins H, Kelly DP, Judge  DP, Chen H-SV: Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs. Nature. 2013; Feb 7;494:105-110. PMCID: PMC3573229

Valtat B, Riveline JP, Zhang P, Singh-Estivalet A, Armanet M, Venteclef N, Besseiche A, Kelly DP, Tronche F, Ferre P, Gautier JF, Breant B, Blondeau B: Fetal PGC-1α overexpression programs adult pancreatic β cell dysfunction. Diabetes. 2013; Apr; 62(4):1206-1216. PMCID: PMC3609553

Chambers KT, Chen Z, Crawford PA, Fu X, Burgess SC, Lai L, Leone TC, Kelly DP, Finck BN: Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding. PLoS ONE. 2012;7(12):e252645. PMCID: PMC3532159

Mitra R, Nogee D, Zechner JF, Yea K, Gierasch CM, Kovacs A, Medeiros DM, Kelly DP, Duncan JP: The transcriptional coactivators, PGC-1α and β cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance. J Mol Cell Cardiol. 2012 Mar; 52:701-710. PMCID: PMC3294189

Gan Z, Burkart-Hartman EM, Han D-H, Finck B, Leone TC, Smith EY, Ayala JE, Holloszy J, Kelly DP: The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2. Genes Dev. 2011; 25:2619-2630. PMCID: PMC3248683

Leone TC and Kelly DP: Transcriptional Control of Cardiac Fuel Metabolism and Mitochondrial Function. Cold Spring Harb Symp Quant Biol. 2011; 76:175-182. PMCID: PMC3340448

Schilling J and Kelly DP: The PGC-1 Cascade as a Therapeutic Target for Heart Failure. J Mol Cell Cardiol. 2011 Oct; 51(4):578-583. PMCID: PMC3042046

Razani B, Zhang H, Schulze PC, Schilling JD, Lodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW, Nichols CG, Semenkovich CF: Fatty acid synthase modulates homeostatic responses to myocardial stress. J Biol Chem. 2011; Sep 2;286(35):30949-30961. PMCID: PMC3162454

Schilling J, Lai L, Sambandam N, Dey CE, Leone TC, Kelly DP: Toll-like receptor-mediiated inflammatory signaling reprograms cardiac energy metabolism by repressing peroxisome proliferator-activated receptor γ coactivator-1 signaling. Circ Heart Fail. 2011 Jul; 4(4):472-482. PMCID: PMC3144030

Chambers KT, Leone TC, Sambandam N, Kovacs A, Wagg CS, Lopaschuk GD, Finck BN, Kelly DP: Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response. J Biol Chem. 2011 Apr 1; 286(13):11155-11162. PMCID: PMC3064169

Kelly DP: Cell Biology: Ageing Theories Unified. Nature. 2011 Feb 17; 470:342-343.

Zechner C, Lai L, Zechner JF, Geng T, Yan Z, Rumsey JW, Collia D, Chen Z, Wozniak DF, Leone TC, Kelly DP: Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity. Cell Metab. 2010 Dec 1; 12(6):633-642. PMCID: PMC2999961

Kelly DP: Introduction to the Nuclear Receptor Review Series. Circ Res. 2010 May; 106(10):1557-1558.

Lai L, Leone TC, Zechner C, Schaeffer PJ, Kelly SM, Flanagan DP, Medeiros DM, Kovacs A, Kelly DP: Transcriptional coactivators PGC-1alpha and PGC-1beta control overlapping programs required for perinatal maturation of the heart. Genes Dev. 2008 Jul 15; 22(14):1948-1961. PMCID: PMC2492740

Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP: The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. Am J Physiol Heart Circ Physiol. 2008 Jul; 295(1):H185-196. PMCID: PMC2494758

Burkart EM, Sambandam N, Han X, Gross RW, Courtois M, Gierasch CM, Shoghi K, Welch MJ, Kelly DP: Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart. J Clin Invest. 2007 Dec; 117(12):3930-3939.

Wende AR, Schaeffer PJ, Parker GJ, Zechner C, Han D-H, Chen MM, Hancock CR, Huss JM, McClain DA, Holloszy JO, Kelly DP: A role for the transcriptional coactivator PGC-1alpha in muscle refueling. J Biol Chem. 2007 Oct 11; 282(50):36642-36651.

Huss JM, Imahashi K, Dufour CR, Weinheimer CJ, Courtois M, Kovacs A, Giguère V, Murphy E, and Kelly DP: The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell Metab. 2007; 6:25-37.

Duncan JG, Fong JL, Medeiros DM, Finck BN, and Kelly DP: Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the PPARalpha -PGC-1alpha gene regulatory pathway. Circulation. 2007; 115:909-917.

Yang J, Sambandam N, Han X, Gross RW, Courtois M, Kovacs A, Febbraio M, Finck BN, and Kelly DP: CD36 deficiency rescues lipotoxic cardiomyopathy. Circ Res. 2007; 100:1208-1217.

Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence, Jr. JC, and Kelly DP: Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab. 2006; 4:199-210.

Wende AR , Huss JM, Schaeffer PJ, Giguère V, and Kelly DP: PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: A mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol. 2005; 25:10684-10694.

Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, and Kelly DP: A potential link between muscle peroxisome proliferator-activated receptor alpha signaling and obesity-related diabetes. Cell Metab. 2005; 1:133-144.

Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, O Holloszy J, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP: PGC-1α deficiency causes multi-system energy metabolic derangements: Muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 2005 Mar 15; 3(4):e101.

Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, and Kelly DP: A potential link between muscle peroxisome proliferator-activated receptor-α signaling and obesity-related diabetes. Cell Metab. 2005; 1:133-144.

Huss JM, Kelly DP: Mitochondrial energy metabolism in heart failure: a question of balance. J Clin Invest. 2005 Mar; 115(3):547-555.

Russell LK, Finck BN, Kelly DP: Mouse models of mitochondrial dysfunction and heart failure. J Mol Cell Cardiol. 2005 Jan; 38(1):81-91.

Huss JM, Torra IP, Staels B, Giguere V, Kelly DP: Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor α signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol. 2004 Oct; 24(20):9079-9091.

Huss JM, Kelly DP: Nuclear receptor signaling and cardiac energetics. Circ Res. 2004 Sep 17; 95(6):568-578.

Schaeffer PJ, Wende AR, Magee CJ, Neilson JR, Leone TC, Chen F, Kelly DP: Calcineurin and calcium/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscle. J Biol Chem. 2004 Sep 17; 279(38):39593-39603.

Kelly DP, Scarpulla RC: Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 2004 Feb 15; 18(4):357-368.

Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE, Medeiros DM, Valencik ML, McDonald JA, Kelly DP: Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ Res. 2004 Mar 5; 94(4):525-533. Epub 2004 Jan 15.

Finck BN, Lehman JJ, Barger PM, Kelly DP: Regulatory networks controlling mitochondrial energy production in the developing, hypertrophied, and diabetic heart. Cold Spring Harb Symp Quant Biol. 2002; 67:371-382.

Kelly DP. PPARs of the heart: three is a crowd: Circ Res. 2003; 92(5):482-484.

Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, Kovacs A, Gross RW, Kelly DP: A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci. USA 2003; 100(3):1226-1231.

Bernal-Mizrachi C, Weng S, Feng C, Finck BN, Knutsen RH, Leone TC, Coleman T, Mecham RP, Kelly DP, Semenkovich CF: Dexamethasone induction of hypertension and diabetes is PPARalpha dependent in LDL receptor-null mice. Nat Med. 2003; 8:1069-1075.

Huss JM, Kopp RP, Kelly DP: Peroxisome proliferator-activated receptor coactivator-1α (PGC-1α) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-α and -γ. Identification of novel leucine-rich interaction motif within PGC-1α. J Biol Chem. 2002; 277(43):40265-40274.

Finck BN, Lehman JJ, Leone TC, Welch MJ, Bennett MJ, Kovacs A, Han X, Gross RW, Kozak R, Lopaschuk G, and Kelly DP: The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus. J Clin Invest. 2002; 109:121-130.

Barger P, Browning AC, Garner AN, and Kelly DP: p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor α: A potential role in the cardiac metabolic stress response. J Biol Chem. 2001; 276:44495-44501.

Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros D, and Kelly DP: Peroxisome proliferator-activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest. 2000; 106:847-856.

Barger P and Kelly DP: PPAR signaling in the control of cardiac energy metabolism. Trends in Cardiovasc Med. 2000; 10:238-245.

Barger PM, Brandt J, Leone TC, Weinheimer CJ, and Kelly DP: Deactivation of the peroxisome proliferator-activated receptor α during cardiac hypertrophic growth. J Clin Invest. 2000; 105:1723-1730.

Vega R, Huss, JM, and Kelly DP: The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol. 2000; 20(5):1868-1876.

Sack MN, Disch D, Rockman H, and Kelly DP: A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl Acad Sci. USA 1997; 94:6438-6443.

Sack MN, Rader TA, Park S, Bastin J, McCune SA, Kelly DP: Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation. 1996; 94:2837-2842.