Publications List - Huaxi Xu

1.      Xu H, Shields D. (1993) Prohormone processing in the trans-Golgi network: endoproteolytic cleavage of prosomatostatin and formation of nascent secretory vesicles in permeabilized cells. The Journal of Cell Biology. 122(6):1169-84. PMCID: 2119863

2.      Xu, H., and Shields, D.  (1994) Prosomatostatin processing in permeabilized cells. Endoproteolytic cleavage is mediated by a vacuolar ATPase that generates an acidic pH in the trans-Golgi network.  J. Biol. Chem. 269(36):22875-81. PMID: 7915719

3.      Xu, H., and Shields, D.  (1994) Prohormone processing in permeabilized cells: endoproteolytic cleavage of prosomatostatin in the trans-Golgi network.  Biochimie 76(3-4):257-64. PMID: 7819332

4.      Xu, H., Greengard, P., and Gandy, S.  (1995) Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein. J. Biol. Chem. 270(40):23243-5. PMID:07559474

5.      Musch, A., Xu, H., Shields, D., and Rodriguez-Boulan, E.  (1996). Transport of vesicular stomatitis virus G protein to the cell surface is signal mediated in polarized and nonpolarized cells.   J. Cell Biol.  133(3):543-58. PMCID: PMC2120809

6.      Xu, H., Sweeney, D., Greengard, P., and Gandy, S.  (1996). Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system.  Proc. Natl. Acad. Sci.  USA.  93(9):4081-4. PMCID: PMC39490

7.      Xu, H., Sweeney, D., Wang, R., Thinakaran, G., Lo, A. C. Y., Sisodia, S., Greengard, P., and Gandy, S.  (1997) Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proc. Natl. Acad. Sci. USA.  94(8):3748-52. PMCID: PMC20512

8.      Gouras GK, Xu H, Jovanovic JN, Buxbaum JD, Wang R, Greengard P, Relkin NR, Gandy S. (1998) Generation and regulation of beta-amyloid peptide variants by neurons. Journal of neurochemistry. 1998;71(5):1920-5. PubMed PMID: 9798916.

9.      Xu, H., Gouras, GK., Greenfield, JP., Vincent, B, Naslund, J., Mazzarelli, L, Jovanovic, J. N, Seeger, M, Relkin, NR, Liao, F., Checler, F., Buxbaum, JD, Chait, BT., Thinakaran, G., Sisodia, S., Wang, R., Greengard, P., and Gandy, S.  (1998). Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.  Nature Medicine 4(4):447-51. PMID: 9546791

10.  Greenfield, JP., Tsai, J., Gouras, GK., Hai, B., Thinakaran, G., Checler, F., Sisodia, SS., Greengard, P., and Xu, H.  (1999). Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.  Proc. Natl. Acad. Sci. USA 96(2):742-7. PMCID: PMC15207

11.  Greenfield, JP., Xu, H., Greengard, P., Gandy, S. and Seeger, M. (1999).  Generation of the amyloid-beta peptide N terminus in Saccharomyces cerevisiae expressing human Alzheimer's amyloid-beta precursor protein.  J. Biol. Chem. 274(48):33843-6. PMID: 10567340

12.  Gouras, GK., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Greenfield, JP., Haroutunian, V., Buxbaumn, JD., Xu, H., Greengard, P. and Relkin, NR. (2000) Intraneuronal Abeta42 accumulation in human brain. Am. J. Path. 156(1):15-20. PMCID: PMC1868613

13.  Gouras, GK.*, Xu, H.*, Gross, R., Greenfield, JP., Hai, B., Wang, R., and Greengard, P. (2000) Testosterone reduces neuronal secretion of Alzheimer beta-amyloid peptides. Proc. Natl. Acad. Sci. USA 97(3):1202-5. (*, equal contribution). PMCID: PMC15568

14.  Greenfield, JP., Gross, RS., Gouras, GK., and Xu, H. (2000). Cellular and molecular basis of beta-amyloid precursor protein metabolism. Frontiers in Bioscience. 5:D72-83. PMID: 10702374

15.  Gasparini, L., Gouras, GK., Gross RS. Beal, MF., Wang, R., Greengard, P., and Xu, H. (2001) Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J. Neurosci. 21(8):2561-70. PMID: 11306609

16.  Yan, R., Han, P., Miao, H., Greengard, P., and Xu, H. (2001) The transmembrane domain of the Alzheimer’s beta-secretase (BACE1) determines its late Golgi localization and access to beta-amyloid precursor protein (APP) substrate.  J. Biol. Chem. 276(39):36788-96. PMID: 11466313

17.  Yu, C.*, Kim, SH.*,  Ikeuchi, T.*, Xu, H.*, Gasparini, L., Wang, R., and Sisodia, SS. (2001) Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.  J. Biol. Chem. 276(47):43756-60. (*, equal contribution). PMID: 11583985

18.  Gasparini, L., Netzer, W., Greengard, P., and Xu, H. (2002) Does insulin dysfunction play a role in Alzheimer's disease? Trends in Pharmacological Sciences 23(6):288-93. PMID: 12084635

19.  Greenfield, JP., Leung, L, Cai, D., Kaasik, K., Gross, R., Rodriguez-Boulan, E., Greengard, P. and Xu, H. (2002) Estrogen lowers Alzheimer’s beta-amyloid peptide generation by stimulating trans-Golgi network vesicle biogenesis.  J. Biol. Chem. 277(14):12128-36. PMID: 11823458

20.  Leem JY., Saura CA., Pietrzik C., Chrstianson, J., Wanamaker, C., King, L., Veselits ML., Tomita, T., Gasparini, L., Iwatsubo, T., Xu, H., Green, WN., Koo, EH., and Thinakaran, G. (2002) A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol. Dis. 11(1):64-82. PMID: 12460547

21.  Leem, JY., Vijayan, S., Han, P., Cai, D., Machura, M., Lopes, KO., Veselits, ML., Xu, H., and Thinakaran, G. (2002) Presenilin 1 is required for maturation and cell surface accumulation of nicastrin.  J. Biol. Chem. 277(21):19236-40. PMID: 11943765

22.  Lu, Z., Murray, J., Luo, W., Li, H., Xu, H., Backer, JM., and Chen, Y. G. (2002) Transforming growth factor beta activates Smad2 in the absence of receptor endocytosis. J. Biol. Chem. 277(33):29363-8. PMID:12034739

23.  Luo, Y., Smith, JV., Netzer, WJ., Curry, KJ., Buford, JP., Paramasivam, V., Khan, I., Manceva, SD., Xu, H., Butko, P. (2002). Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761. Proc.  Natl. Acad. Sci. USA 99(19):12197-202. PMCID: PMC129421

24.  Takahashi, RH., Milner, TA., Li, F., Nam, EE., Edgar, MA., Yamaguchi, H., Beal, MF., Xu, H., Greengard, P., and Gouras, GK. (2002) Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol 161(5)1869-79. PMCID: PMC1850783

25.  Zheng, H*, Xu, H.*, Uljon, SN., Gross, R., Hardy, K., Gaynor, J., Lafrancois, J., Simpkins, J., Refolo, LM., Petanceska, S., Wang, H and Duff, K. (2002) Modulation of A(beta) peptides by estrogen in mouse models.  J. Neurochem. 80(1):191-6. (*, equal contribution). PMID: 11796757

26.  Cai, D. Leem, JY., Greenfield, JP., Wang, P., Wang, R., Lopes, KO., Kim, SH., Zheng, H., Greengard, P., Sisodia, SS., Thinakaran, G., and Xu, H. (2003) Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. J. Biol. Chem. 278(5):3446-54. PMID: 12435726

27.  Dou, F., Netzer, WJ., Takashima, A., and Xu, H. (2003) “Heat Shock Proteins Reduce Aggregation And Facilitate Degradation Of Tau Protein”, International Congress Series 1790, The Elsevier Science. (Book Section)

28.  Dou, F., Netzer, WJ., Tanemura, K., Li, F., Hartl, FU., Takashima, A., Gouras GK., Greengard, P., and Xu, H. (2003) Chaperones increase association of tau protein with microtubules.  Proc. Natl. Acad. Sci. USA 100(2):721-6. PMCID: PMC141063

29.  Gasparini, L and Xu, H. (2003) Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends in Neurosciences 26(8):404-6. PMID: 12900169

30.  Liu, SJ., Zhang, AH., Li, HL., Wang, Q., Deng, HM., Xu, H., and Wang, JZ. (2003) Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. J. Neurochem. 87(6):1333-44. PMID: 14713290

31.  Luo, W., Wang, H., Li, H., Kim, BS., Shah, S., Lee, HJ., Thinakaran, G., Kim, TW., Yu, G., and Xu, H. (2003) PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J. Biol. Chem. 278(10):7850-4. PMID: 12522139

32.  Netzer, WJ., Dou, F., Cai, D., Veach, D., Jean, S., Li, Y., Bornmann, WG., Clarkson, B., Xu, H., and Greengard, P. (2003) Gleevec inhibits eta-amyloid production but not Notch cleavage. Proc. Natl. Acad. Sci. USA 100(21):12444-9. PMCID: PMC218777

33.  Campbell W, Wolfe M, Xu H. (2004) Cell-free reconstitution of beta-amyloid production and trafficking. In: Xia W, Xu H, editors. Amyloid Precursor Protein: A Practical Approach: The CRC Press p.51-68. (Book Section)

34.  Gasparini, L., Rusconi, L. Xu, H., del Soldato, P., and Ongini, E., (2004) Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures. J. Neurochem. 88(2):337-48. PMID: 14690522

35.  Vetrivel, KS., Cheng, H., Sakurai, K., Li, T., Nukina, N., Wong, P.C., Xu, H. and Thinakaran, G. (2004) Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. J. Biol. Chem. 279(43):44945-54. PMCID: PMC1201506

36.  Wang, H., Luo, WJ., Zhang, YW., Li, Y., Thinakaran, G., Greengard, P., and Xu, H. (2004) Presenilins and amma-secretase inhibitors affect intracellular trafficking and cell surface localization of the amma-secretase complex components. J. Biol. Chem. 279(39):40560-6. PMID: 15247291

37.  Han, P., Dou, F., Li, F., Zhang, X., Zhang YW., Zheng, H., Lipton, SA., Xu, H.*, and Liao*, FF. (2005) Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. J. Neurosci. 25(50):11542-52. (*, Co-correspondent Authors). PMID: 16354912

38.  Zhang,YW., Luo, WJ., Wang, H., Lin, P., Vetrivel, KS., Liao, F., Li, F., Wong, PC., Farquhar, MG., Thinakaran, G. and Xu, H. (2005) Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components. J. Biol. Chem. 280(17):17020-6. PMCID: PMC1201533

39.  Cai, D., Netzer WJ., Zhang, M., Lin, Y., Du, G., Frohman, M., Foster, DA., Sisodia, SS., Xu, H., Gorelick, FS., and Greengard, P. (2006) Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. Proc. Natl. Acad. Sci. 103(6):1941-6. PMCID: PMC1413665

40.  Cai, D., Zhong, M., Wang, R., Netner, WJ., Shields, D., Zheng, H., Sisodia SS., Foster, DA., Gorlick, SF., Xu, H.*, and Greengard, P*. (2006) Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer’s disease-linked presenilin-1 mutant neurons. Proc. Natl. Acad. Sci. 103(6):1936-40. (*, Co-correspondent Authors). PMCID: PMC1413666

41.  He, G, Qing, H, Cai, F, Kwok, C, Xu, H, Yu, G, Bernstein, A, and Song, W. (2006) Ubiquitin-proteasome pathway mediates degradation of APH-1. J. Neurochem. 99(5):1403-12. PMID: 17059559

42.  Vetrivel, KS., Zhang, YW., Xu, H., and Thinakaran, G. (2006) Pathological and physiological functions of presenilins. Mol Neurodegeneration. 1:4. doi: 10.1186/1750-1326-1-4. PMCID: PMC1513131

43.  Wang, R, Zhang, YW., Sun, P., Liu, R., Xia, K., Xia, JH., Xu, H.*, and Zhang, Z*. (2006) Transcriptional regulation of PEN-2, a key component of the amma-secretase complex, by CREB. Mol Cell Biol. 26(4):1347-54. (*, Co-correspondent Authors). PMCID: PMC1367199

44.  Wang, R., Zhang, YW, Zhang, X., Liu, R., Zhang, X., Hong, SH., Xia, K., Xia, J., Zhang, Z., and Xu, H. (2006) Transcriptional regulation of APH-1A and increased amma-secretase cleavage of APP and Notch by HIF-1 and hypoxia. FASEB J.  20(8):1275-7. PMID: 16645044

45.  Wang, ZF., Li, HL., Li, XC., Zhang, Q., Tian, Q., Wang, Q., Xu, H. and Wang, JZ. (2006) Effects of endogenous beta-amyloid overproduction on tau phosphorylation in cell cultures. J. Neurochem. 98(4):1167-75. PMID: 16762022

46.  Xu, H.*, Wang, R., Zhang, YW., Zhang, X. (2006) Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer's disease. Ann N Y Acad. Sci. 1089:324-42. doi: 10.1196/annals.1386.036. PMID: 17261779

47.  Zhang, X., Li, F., Bulloj, A., Zhang, YW., Tong, G., Zhang, Z., Liao, FF., and Xu, H. (2006) Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules. FASEB J.  20(8):1272-4. PMCID: PMC16645045

48.  Zhang, X., Li, F., Zhang, YW., Tong, G., Zhang, Z., Liao, FF., and Xu, H. (2006) Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of FTDP-17 mutant Tau. Mol. Neurodegeneration. 1:7. doi: 000294861. PMCID: PMC1559623

49.  Gandy, S., Zhang, YW., Schmidt, SD., Ikin, A., Nixon, RA., Liao, FF., Mathews, PM., Xu, H., and Ehrlich, ME. (2007) Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. J. Neurochem. 102(3):619-26 PMID: 17630980

50.  Li, HL, Wang, HH, Liu, SJ, Deng, YQ, Zhang, YJ, Tian, Q, Wang, XC, Chen, XQ, Yang, Y, Zhang, JY, Wang, Q, Xu, H, Liao, FF, Wang, JZ. (2007) Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration. Proc. Natl. Acad. Sci.  104(9):3591-6. PMCID: PMC1805527.

51.  Lin, P., Li, F., Huang, H., Zhang, YW., Tong, GG., Farquhar, MG., Xu, H. (2007) Calnuc binds to Alzheimer’s beta-amyloid precursor protein and affects its biogenesis. J. Neurochem. 100(6):1505-14. PMID: 17348862

52.  Zhang, X., Zhou, K., Wang, R., Cui, J., Lipton, SA., Liao, FF., Xu, H.*, and Zhang, YW.* (2007) Hypoxia inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. J. Biol. Chem. 282(15):10873-80. (*, Co-correspondent Authors) PMID: 17303576

53.  Zhang, YW, Wang, R., Liu, Q., Zhang, H., Liao, FF., and Xu, H. (2007) Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc. Natl. Acad. Sci. 104(25):10613-8. PMCID: PMC1888796

54.  Zhang, YW, and Xu, H. (2007) Molecular and cellular mechanisms for Alzheimer's disease: understanding APP metabolism. Current Molecular Medicine. 7(7):687-96. PMID: 18045146

55.  Zhang, YW, and Xu, H. (2007) Alteration of beta-secretase traffic by the receptor tyrosine kinase signaling pathway – a new mechanism for regulating Alzheimer’s beta-amyloid production. Cell Res. 17(5):385-6 PMID:17496905

56.  Bulloj, A., Leal, MC., Surace, EI., Zhang, X., Xu, H., Ledesma, MD., Castano, EM., and Morelli, L. (2008) Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation. Mol. Neurodeger. 3:22. PMCID: PMC2648957

57.  Xiong, H., Callaghan, D., Jones, A., Walker, DG., Lue, LF., Beach, TG., Sue, LI., Woulfe, J., Xu, H., Stanimirovic, DB., and Zhang W. (2008) Cholesterol retention in Alzheimer’s brain is responsible for high beta- and gamma-secretase activities and Abeta production. Neurobiol. Dis. 29(3):422-37. PMCID: PMC2720683

58.  Zhang, H., Wang, R., Liu, R., Hong, S., Xu, H.*, and Zhang YW* (2008) Presenilins regulate the cellular levels of tumor suppressor PTEN. Neurobiol. Aging 229(5):653-60. (*, Co-correspondent Authors). PMCID: PMC4405252

59.  Chen, Y., Zhou, K., Wang, R., Liu, Y., Kwak, YD., Ma, T., Thompson, RC., Zhao, Y., Smith, L., Gasparini, L., Luo, Z., Xu, H., and Liao, FF. (2009) Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription. Proc. Natl. Acad. Sci. 106(10):3907-12. PMCID: PMC2656178

60.  Dunys, J., Sevalle, J., Giaimei, E., Pardossi-Piquard, R., Vitek, MP., Renbaum, P., Levy-Lahad, E., Zhang, YW., Xu, H., Checler, F., and da Costal, CA. (2009) p53-dependent control of transactivation of the Pen2 promoter by presenilins. J. Cell. Sci. 122(Pt 21):4003-8.  PMCID: PMC3188804

61.  Liao, FF., and Xu, H. (2009) Insulin signaling in sporadic Alzheimer's disease. Science Signaling, 2(74):pe36. PMCID: PMC4419569

62.  Liu, Y., Zhang, YW., Wang, X., Zhang, H., You, X., Liao, FF., and Xu, H. (2009) Intracellular trafficking of presenilin 1 is regulated by eta-amyloid precursor protein and phospholipase D1. J. Biol. Chem. 284(18):12145-52. PMCID: PMC2673283

63.  Ma, T., Zhao, YB., Kwak, YD., Thompson, R., Luo, Z., Xu, H., and Liao, FF. (2009) Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events likely via rho-ROCK signaling. J. Neurosci. 29(36):11226-36. PMCID: PMC2757921

64.  You, X., Zhang, YW., Chen, Y., Huang, X., Xu, R., Cao, X., Chen, J., Liu, Y., Zhang, X., and Xu, H. (2009) Retinoid X receptor-alpha mediates (R)-flurbiprofen’s effect on the levels of Alzheimer’s eta-amyloid. J. Neurochem. 111(1):142-9. PMCID: PMC3401643

65.  Zhang, YW., Liu, L., Zhang, X., Li, WB., Chen, Y., Huang, X., Sun, L., Luo, W.,  Netzer, WJ., Threadgill, R., Wiegand, G., Wang, R., Cohen, SN., Greengard, P., Liao, FF., Li, L., and Xu, H. (2009) A functional mouse retroposed gene Rps23r1 reduces Alzheimer’s beta-amyloid levels and tau phosphorylation. Neuron 64(3):328-40. PMCID: PMC3846276

66.  Bulloj, A., Leal, MC., Xu, H., Castano, EM., and Morelli, L. (2010) Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-beta-degrading protease. J. Alzheimer’s Dis. 19(1):79-95. PMCID: PMC4414343

67.  Huang X, Chen Y, Li WB, Cohen SN, Liao FF, Li L, Xu H* and Zhang YW* (2010) The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer’s eta-amyloid level and tau phosphorylation. Hum Mol Genet, 19(19):3835-43 (*Co-correspondent authors). PMCID: PMC2935860

68.  Kwak, YD., Ma, T., Diao, S., Zhang, X., Chen, Y. Hsu, J., Lipton, SA. Masliah, E., Xu, H. and Liao FF. (2010) NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration Molecular Neurodegeneration 5:49. PMCID: PMC2992530

69.  Kwak, YD., Wang, B., Pan, W., Xu, H., Jiang, X., and Liao, FF. (2010) Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc. J. Biol. Chem. 285(13):9847-57. PMCID: PMC2843233

70.  Zhang, YW., and Xu, H. (2010) Substrate check for gamma-secretase. Nat. Struct. & Mol. Biol. 17(2):140-1. PMID: 20130572

71.  Kwak YD, Wang R, Li JJ, Zhang YW, Xu H, Liao FF. (2011) Differential regulation of BACE1 expression by oxidative and nitrosative signals. Molecular Neurodegeneration 6:17. PMCID: PMC3059281

72.  Yao, G., Zong, Y., Gu, S., Zhou, J., Xu, H., Mathews, I., and Jin, R., (2011) Crystal structure of the glutamate receptor GluA1 N-terminal domain. Biochem J. 438(2):255-63. PMCID: PMC3296483

73.  Zhang, YW., Thompson, R., Zhang, H. and Xu, H. (2011) APP processing in Alzheimer’s disease. Mol Brain 4:3. PMCID: PMC3022812

74.  Chen, Y., Huang, X., Zhang, YW., Rockenstein, E., Bu, G., Golde, TE., Masliah, E., and Xu, H. (2012) Alzheimer’s eta-secretase (BACE1) regulates the cAMP/CREB/PKA pathway independently of beta-amyloid J. Neurosci., 32(33):1139011395. PMCID: PMC3446780

75.  Huang, X., Chen, Y., Zhang, H., Ma, Q., Zhang, YW., and Xu, H. (2012) Salubrinal attenuates eta-amyloid-induced neuronal death and microglial activation by inhibition of the NFappaB pathway. Neurobiol. Aging. 33(5):1007.e9 –17. PMCID: PMC3294262

76.  Kwak, YD., Wang, B., Li, JJ., Wang, R., Deng, Q., Diao, S., Chen, Y., Xu, R., Masliah, E., Xu, H., Sung, JJ., and Liao, FF. (2012) Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration. J. Neurosci. 32(32):10971-81. PMCID: PMC3681290

77.  Li, J., Kanekiyo, T., Shinohara, M., Zhang, YW., LaDu MJ., Xu, H., and Bu G. (2012) Differential regulation of amyloid-beta endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms. J. Biol. Chem. 287(53):44593-601. PMCID: PMC3531774

78.  Zhang, H., Zhang, YW., and Xu, H. (2012) Proteolytic processing of Alzheimer’s eta-amyloid precursor protein. J. Neurochem. 120 Suppl 1:9-21. PMCID: PMC3254787

79.  Zhang, H., Zhang,YW., Chen, Y., Huang, X., Zhou, F., Wang, W., Xian, B., Zhang, X., Masliah, E., Chen, Q.,  Han, JD. J., Bu, G., Reed, JC., Liao, FF., Chen, YG., and Xu, H. (2012) Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration. J. Neurosci. 32(44):15565-76. PMCID: PMC3509748

80.  Chen, X., Zhang, YW., Xu, H., and Bu, G. (2013) Transcriptional regulation and its misregulation in Alzheimer's disease. Mol. Brain 6:44. PMCID: PMC3854070

81.  Li, X., Liu, Y., Zheng, Q., Yao, G., Cheng, P., Bu, G., Xu, H., and Zhang, YW. (2013) Ferritin light chain interacts with PEN-2 and affects gamma-secretase activity. Neurosci Lett. 548:90-4. PMCID: PMC3724929

82.  Liu, CC., Kanekiyo, T., Xu, H., and Bu, G. (2013) Apolipoprotein E and Alzheimer’s disease: risk, mechanisms, and therapy. Nature Review Neurology 9(2):106-18. PMCID: PMC3726719

83.  Nakanishi, N., Ryan,S., Zhang, X., Khan, A., Holland, T., Cho, EG., Huang, X., Liao, FF.,  Xu, H., Lipton, SA., and Tu, S. (2013) Synaptic protein alpha1-takusan mitigates amyloid-beta-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites.  J. Neurosci. 33(35):14170-83. PMCID: PMC3756761

84.  Sun, L., Zhao, Y., Zhou, K., Hudson, FH., Zhang, YW., and Xu, H (2013) Insufficient ER-stress response causes selective mouse cerebellar granule cell degeneration resembling that seen in congenital disorders of glycosylation. Mol. Brain 6:52. PMCID: PMC3907076

85.  Wang, X., Zhao, Y., Zhang, X., Badie, H., Zhou, Y, Mu, Y, Loo, LS., Cai, L., Thompson, R., Yang, B., Chen, Y., Johnson, PF., Wu, C., Mobley, W., Zhang, D., Gage, FH., Ranscht, B., Zhang, YW., Lipton, SA., Hong, W., and Xu, H. (2013) Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulation of glutamate receptor recycling in Down’s Syndrome. Nature Medicine 19(4):473-80. PMCID: PMC3911880

86.  Zhang, YW., Chen, Y., Liu, Y., Zhao, Y., Liao, FF., and Xu H. (2013) APP regulates NGF receptor trafficking and NGF-mediated neuronal differentiation and survival. PLoS One, 8(11):e80571. PMCID: PMC3815101

87.  Chen, HY., Lu, QY., Zhang, YW., Zhang, CL., Zhang, H., and Xu, H. (2014) Overexpression of SLC25A38 protein in acute lymphoblastic leukemia cells. Oncology Letters 7(5):1422-6. PMCID: PMC3997699

88.  Chen, Y., Wang, B., Liu, D., Li, JJ., Xue, Y., Sakata, K., Zhu, LQ., Heldt, S., Xu, H., and Liao, FF. (2014) Hsp90 chaperone inhibitor 17-AAG attenuates Aeta-induced synaptic toxicity and memory impairment. J. Neurosci. 34(7):2464-70. PMCID: PMC3921421

89.  Jiang, S., Li, Y., Zhang, C., Zhao, Y., Bu, G., Xu, H., and Zhang, YW. (2014) M1 muscarinic acetylcholine receptor in Alzheimer's disease. Neurosci Bull. 30(2):295-307. PMCID: PMC24590577

90.  Jiang, S., Li, Y., Zhang, X., Bu, G., Xu, H., and Zhang, YW. (2014) Trafficking regulation of proteins in Alzheimer's disease. Mol. Neurodegener. 9:6. PMCID: PMC3891995

91.  Kanekiyo, T., Xu, H., and Bu, G. (2014) ApoE and Aeta in Alzheimer’s disease: accidental encounters or partners? Neuron 81(4):740-54. PMCID: PMC3983361

92.  Liu, CC., Tsai, CW., Deak, F., Rogers, J., Penuliar, M., Sung, YM., Maher, JN., Fu, Y., Li, X., Xu, H., Estus, S,, Hoe, HS., Fryer, JD., Kanekiyo, T., and Bu, G. (2014) Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease. Neuron, 84(1):63-77. PMCID: PMC4199382

93.  Niu, M., Hu, J., Wu, S., Zhang, X., Xu, H. Zhang, Y., Zhang, J., Yang, Y. (2014) Structural bioinformatics-based identification of EGFR inhibitor gefitinib as a putative lead compound for BACE. Chem. Biol. Drug Des. 83(1):81–8. PMID: 24516878

94.  Tu, S., Okamoto SI., Lipton, SA., and Xu, H. (2014) Oligomeric Abeta-induced synaptic dysfunction in Alzheimer's disease. Mol. Neurodegener. 9(1):48. PMCID: PMC4237769

95.  Wang, X., Huang, T., Bu, G. and Xu, H. (2014) Dysregulation of protein trafficking in neurodegeneration. Mol. Neurodegener. 9:31. PMCID: PMC4237948

96.  Wang, X., Zhao, Y., Huang, T., Thompson, R., Zhang, YW., Hong, W., and Xu, H. (2014) Sorting nexin 27 regulates Abeta production through modulating gamma-secretase activity. Cell Report 9(3):1023-33 PMCID: PMC4328673

97.  Zhang X, Li Y, Xu H, Zhang YW. (2014) The gamma-secretase complex: from structure to function.  Frontiers in Cellular Neuroscience. 8:427. PMCID: PMC4263104.

98.  Atagi Y, Liu CC, Painter MM, Chen XF, Verbeeck C, Zheng H, Li X, Rademakers R, Kang SS, Xu H, Younkin S, Das P, Fryer JD, Bu G., (2015) Apolipoprotein E is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). J Biol. Chem. 290(43):26043-50. PMCID: PMC4646257

99.  Cao, L., Zhou, J., Zhang, J.R., Wu, S., Yang, X., Zhao, X., Li, H.F., Luo, M., Yu, Q., Lin, G., Lin, H., Xie, J., Li, P., Hu, X., Zheng C., Bu, G., Zhang, YW., Xu, H.*, Yang, Y., Huang, C., and Zhang, J.* (2015) Cyclin-dependent kinase 5 decreases in gastric cancer and its nuclear accumulation suppresses gastric tumorigenesis. Clinical Cancer Research. 21(6):1419-28. (*Co-corresponding authors). PMID: 25609066

100.    Chen XF, Wei Z, Wang T, Zhang ZL, Wang Y, Heckman MG, Diehl NN, Zhang YW, Xu H, Bu G., (2015) Demographic and Lifestyle Characteristics, but Not Apolipoprotein E Genotype, Are Associated with Intelligence among Young Chinese College Students. PLoS One. 10(11):e0143157 PMCID: PMC4648581

101.    Feng, T., Niu, M., Ji, C., Gao, Y., Wen, J., Bu, G., Xu, H. and Zhang, YW. (2015) SNX15 regulates cell surface recycling of APP and Abeta generation. Mol. Neurobiol. doi: 10.1007/s12035-015-9306-z. PMCID:PMC4691577.

102.    Feng, Y., Liu, T., Dong, SY., Guo, YJ., Jankovic, J., Xu, H., and Wu, YC. (2015) Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells. J. Neurochem.  134(4):668-76. PMID: 25991017

103.    Hou, P., Liu, G., Zhao, Y., Shi, Z., Zheng, Q., Bu, G., Xu, H., and Zhang, YW. (2015) Role of copper and the copper-related protein CUTA in mediating APP processing and Abeta generation. Neurobiol. Aging. 36(3):1310-5. PMID: 25557959

104.    Hu, J., Lin, T., Gao, Y., Xu, J., Jiang, C., Wang, G., Bu, G., Xu, H., Chen, H., Zhang, YW. (2015) The resveratrol trimer miyabenol C inhibits beta-secretase activity and beta-amyloid generation. PlosOne. 10(1):e0115973. doi: 10.1371. PMCID: PMC4309453.

105.    Hu, J., Liu, CC., Chen, XF., Zhang, Y., Xu, H. and Bu, G. (2015) Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Abeta metabolism in apoE4-targeted replacement mice. Mol Neurodegener 10:6. PMCID: PMC4356137

106.    Painter, MM., Atagi, Y., Liu, CC., Rademakers, R., Xu, H., Fryer, JD., and Bu, G. (2015) TREM2 in CNS homeostasis and neurodegenerative disease. Mol. Neurodegener. 10:43. doi: 10.1186/s13024-015-0040-9. PMCID: PMC4560063

107.    Shukla, M., Htoo, HH., Wintachai, P., Hernandez, J., Dubois, C., Postina, R., Xu, H., Checler, F., Smith, DR., Govitrapong, P., and Vincent, B. (2015) Melatonin stimulates the non amyloidogenic processing of betaAPP through the positive transcriptional regulation of ADAM10 and ADAM17. J. Pineal Res. 58(2):151-65 PMID: 25491598

108.    Wang, H., Hara, Y., Liu, X., Reuben, JM., Xie, Y., Xu, H., Bu, G., Pei, Y., Gupta, Y., and Wu, X. (2015) Detection and enumeration of circulating tumor cells based on their invasive property. Oncotarget. 6(29):27304-11. PMC4694991

109.    Zhao, Y., Tseng, IC., Heyser, CJ. Rockenstein, E., Mante M., Adame, A., Zheng, Q., Huang, T., Wang, X., Arslan, PE., Chakrabarty P., Wu, C., Bu, G., Mobley, WC., Zhang, YW., St. George-Hyslop, P., Masliah, E., Fraser, P., and Xu, H. (2015) Appoptosin-mediated caspase-cleavage of tau contributes to progressive supranuclear palsy pathogenesis. Neuron 87(5):963-75. PMCID: PMC4575284

110.    Zhong L, Chen XF, Zhang ZL, Wang Z, Shi XZ, Xu K, Zhang YW, Xu H, Bu G. (2015) DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response. J. Biol. Chem. 290(25):15866-77. PMCID: PMC4505493

111.    Zhou, J., Li, HF., Li, X., Zhang, G., Niu, Y., Yuan, ZQ., Herrup, K., Zhang, YW., Bu, G., Xu, H., and Zhang, J. (2015) The roles of Cdk5-mediated subcellular localization of FOXO1 in neuronal death. J. Neurosci. 35(6):2624-35. PMCID: PMC4582140

112.    Barini, E., Antico, O., Zhao, Y., Asta, F., Tucci, V., Catelani, T., Marotta, R., Xu, H., and Gasparini, L. (2016) Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy. Molecular Neurodegener, 11(1):16 PMCID: PMC4746897

113.    Huang TY, Zhao Y, Li X, Wang X, Tseng IC, Thompson R, Tu S, Willnow TE, Zhang YW, Xu H. (2016) SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein. J. Neurosci.  36(30):7996-8011. PMCID: PMC4961782

114.    Kang R, Li P, Wang T, Li X, Wei Z, Zhang Z, Zhong L, Cao L, Heckman MG, Zhang YW, Xu H, Huang C, Bu G, Chen XF. (2016) Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population. Scientific Reports, 6:19930 PMCID: PMC4730152

115.    Li, Y., Sun, H., Chen, Z., Xu, H., Bu, G., and Zheng, H. (2016) Implications of GABAergic Neurotransmission in Alzheimer’s Disease. Frontiers in Aging Neuroscience. 8:31 PMCID: PMC4763334

116.    Wang, C., Niu, M., Zhou, Z., Zheng, X., Zhang, L., Tian, Y., Yu, X., Bu, G., Xu, H., Ma, Q., and Zhang, YW. (2016) VPS35 regulates cell surface recycling and signaling of dopamine receptor D1. Neurobiol. Aging. 46:22-31. PMCID: PMC5018432

117.    Yan, L., Chen, Y., Li, W., Huang, X., Badie, H., Jian, F., Huang, T., Zhao, Y., Cohen, S.N., Li, L., Zhang, Y. Luo, H., tu, S., Xu, H. (2016), RPS23RG1 reduces Abeta oligomer-induced synaptic and cognitive deficits. Scientific Reports. 6:18668 PMCID: PMC4702092

118.    Zhang, C., Shi, Z., Zhang, L., Zhou, Z., Zheng, X., Liu, G., Bu. G., Fraser P.E., Xu, H. and Zhang, YW. (2016) Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology. J. Cell Sci., 129(5):994-1002 PMCID: PMC4813315

119.    Zhang X, Hu J, Zhong L, Wang N, Yang L, Liu CC, Li H, Wang X, Zhou Y, Zhang Y, Xu H, Bu G, Zhuang  (2016) Quercetin stabilizes apolipoprotein E and reduces brain Abeta levels in amyloid model mice. Neuropharmacology. 108:179-92 PMID: 27114256

120.    Zheng, H., Liu, CC., Atagi, Y., Chen, XF., Jia, L., Yang, L., He, W., Zhang, X., Kang, SS., Rosenberry, TL., Fryer, JD., Zhang ,YW., Xu, H., and Bu, G. (2016) Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation. Neurobiol Aging 42:132-41. doi: 10.1016/j.neurobiolaging.2016.03.004. PMCID: PMC4857884

121.    Zheng H, Tang R, Yao Y, Ji Z, Cao Y, Liu Z, Peng F, Wang W, Can D, Xing H, Bu G, Xu H, Zhang YW, Zheng W. (2016) MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy. Mol Neurobiol. 53(1):1-7. PMID: 25394384.

122.    Zhong L, Xie YZ, Cao TT, Wang Z, Wang T, Li X, Shen RC, Xu H, Bu G, Chen XF. (2016) A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism. Mol Neurodegener. 11(1):2. PMCID: PMC4710020

123.    Zheng Q, Zheng X, Zhang L, Luo H, Qian L, Fu X, Liu Y, Gao Y, Niu M, Meng J, Zhang M, Bu G, Xu H, Zhang YW. (2016) The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death. Mol Neurobiol. Jun 21. PMID: 27324899