Publications   

DS. Wilkinson, JS. Jariwala, E. Anderson, K. Mitra, J. Meisenhelder, JT. Chang, T. Ideker, T. Hunter, V. Nizet, A. Dillin, M. Hansen. “LC3 is a Novel Substrate for the Mammalian Hippo Kinases, STK3/STK4”, Molecular Cell, (2015) May 4;11(5):856-7 doi: 10.1080/15548627.2015.1017197 PMCID: PMC4509446
Link to Article

 

M. Safra, R. Fickentscher, M. Levi-Ferber, YM. Danino, A. Haviv-Chesner, M. Hansen, T. Juven-Gershon, M. Weiss, S. Henis-Korenbilt, “The FOXO Transcription Factor DAF-16 Bypasses ire-1 Requirement to Promote Endoplasmic Reticulum Homeostasis”, Cell Metabolism, (2014) 20(5):870-81. PMID: 25448701, PubMed – in process.
Link to Article

 

M. Nishimura, C. Kumsta, G.Kaushik, S. Diop, Y. Ding, J. Bisharat-Kernizan, H.Catan, A. Cammarato, R. S. Ross, A.J. Engler, R. Bodmer, M. Hansen, K. Ocorr “Dual Role of β1-Integrin and Integrin-Linked Kinase in Modulating Cardiac Aging”, Aging Cell, (2014) Jan. doi: 10.1111/acel.12193. PMCID: PMC4032615.
Link to Article

 

C. Kumsta, T.-T. Ching, M. Nishimura, A. E. Davis, S. Gelino, H. H. Catan, X. Yu, C.-C. Chu, B. Ong, S. H. Panowski, N. Baird, R. Bodmer, A.-L. Hsu, M. Hansen, “Integrin-linked kinase modulates longevity and thermotolerance in C. elegans through neuronal control of HSF-1”, Aging Cell, (2013) Dec. doi: 10.1111/acel.12189. PMCID: PMC4059541.
Link to Article

 

L. R. Lapierre, S. Gelino, C. Daniel De Magalhaes Filho, O. Visvikis, C.-C. Chu, B. Ong, A. Dillin, and M. Hansen, “HLH-30/TFEB is a conserved regulator of autophagy and modulates longevity in C. elegans”, Nature Communications, (2013) Aug 8;4:2267. doi:10.1038/ncomms3267, PMCID: PMC3866206.
Link to Article

 

B. Conti and M. Hansen, “A Cool Way to Live Long”, Cell, 2013 Feb 14;152(4):671-2. doi: 10.1016/j.cell.2013.01.050.  PMID: 23415218.
Link to Article

 

Schiavi, A. Torgovnick, A. Kell, E. Megalou, N. Castelein, I. Guccini, L. Marzocchella, S. Gelino, M. Hansen, F. Malisan, I. Condo, R. Bei, S. Rea, B. P. Braeckman, N. Tavernarakis, R. Testi, N. Ventura, “Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans”, “Reduced expression of frataxin extends C. elegans lifespan via autophagy regulated by p53 and HIF-1”, Experimental Gerontology, (2013) Feb; 48(2). PMCID: PMC3572394
Link to Article

 

M. Hansen, T. Flatt, and H. Aguilaniu, “Reproduction, Fat Metabolism, and Lifespan:  What Is the Connection? ”, Cell Metabolism (2013) Jan 8;17(1):10-9. PMCID: PMC3567776.
Link to Article

 

L. R. Lapierre, M. J. Silvestrini, L. Nuñez, K. Ames, S. Wong, T. T. Le, M. Hansen and A. Meléndez, “Autophagy is required for lipid storage in C. elegans”, Autophagy, (2013) Jan 15; 9(3) (* co-first authors). PMCID: PMC3590250.
Link to Article

 

L. Lapierre, M. Hansen, “ Lessons from C. elegans: Signaling pathways for longevity” Trends in Endocrinology & Metabolism, (2012) Dec; 23(12):637-44. PMCID: PMC3502657.
Link to Article

 

S. Gelino, M. Hansen, “Autophagy – an Emerging Anti-Aging MechanismJ. of Clin Exp Pathol. (2012) doi: 10.4172/2161-0681.S4-006.  PMCID: PMC3674854. 

 

D. Klionsky, F. C. Abdalla, H. Abeliovich,..., M. Hansen, et al., Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.” Autophagy (2012) 8:4, 445–544. PMCID: PMC3404883.
Link to Article

 

C. Kumsta, M. Hansen, “C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germline”. PLoS ONE (2012) 7(5):e35428. PMCID: PMC3344830.
Link to Article

 

L. Lapierre, A. Meléndez and M. Hansen, “Autophagy links lipid metabolism to longevity in C. elegans. Autophagy  (2012) 8(1), 144-6. PMCID: PMC3335999.
Link to Article

 

A. Walker, R. Jacobs, J. Watts, V. Rottiers, K. Jiang, D. Finnegan, T. Shioda, M. Hansen, F. Yang, K. Jiang, L. Niebergall, D. Vance, A. Hart, and A. Naar, “ A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans”, Cell (2011) Nov 11;147(4), 840-52.  PMCID: PMC3384509.
Link to Article

 

A. Duran, R. Amanchy, J. Linares, J. Joshi, S. Abu-Baker, A. Porollo, M. Hansen, and M. Diaz-Meco, “p62 is a key regulator of nutrient sensing in the mTORC1 pathway”, Molecular Cell (2011) Oct 7; 44(1), 134-46. PMCID: PMC3191188.
Link to Article

 

L. Lapierre, S. Gelino, A. Meléndez and M. Hansen, “Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Current Biology  (2011) 21, 1507–14 (featured article, selected article for Faculty of 1000) PMCID: PMC3190169.
Link to Article

 

DF. Egan, DB. Shackelford, MM. Mihaylova, S. Gelino, RA. Kohnz, W. Mair, DS. Vasquez, A. Joshi, DM. Gwinn, R. Taylor, JM. Asara, J. Fitzpatrick, A. Dillin, B. Viollet, M., Kundu, M. Hansen, and RJ. Shaw, “Phosphorylation of (ULK1/hATG1) by AMP-activated protein kinase connects energy sensing to miophagy”, Science (2011), 331(6016): 456-61 PMCID: PMC3030664.
Link to Article

 

M. Hansen and P. Kapahi, “TOR and aging”, Chapter 14 in The Enzymes, Volume 28 (2010), Structure, Function and Regulation of TOR complexes from yeast to mammals, Editors: F. Tamamoi and M. Hall.

 

S. Henis-Korenblit, P. Zhang, M. Hansen, M. McCormick, S-J. Lee, M. Cary and C. Kenyon, “Insulin/IGF-1 Signaling Mutants Reprogram ER-stress Response Proteins to Promote Longevity”, Proc Natl Acad Sci (2010) May 25:107(21): 9730-5.  PMCID: PMC2906894.
Link to Article

 

T. Nakamura, M. Hansen, S. Oldham and S.A. Lipton, “The Neurobiology of Aging: Free Radical Stress and Metabolic Pathways”. In: Brocklehurst's Textbook of Geriatric Medicine and Gerontology, 7th Edition. (2010) Editors: HM. Fillit, K. Rockwood, and K. Woodhouse. Publisher: Elsevier.

 

A. Melendez, D. Hall and M. Hansen, “Monitoring the role of autophagy in C. elegans aging”, Chapter in Methods in Enzymology (2008) 451:493-520. PMID:19185737.
Link to Article


 

M. Hansen, A. Chandra, L. Mitic, B. Onken, M. Driscoll and C. Kenyon, “A Role for Autophagy Genes in the Extension of Lifespan by Dietary Restriction in C. elegans”, PLoS Genetics (2008) Feb; 4(2): e24. PMCID: PMC2242811.
Link to Article

 

S. Taubert, M. Hansen, M. Van Gilst, S. Cooper, and K.Yamamoto, “The Mediator Subunit MDT-15 Confers Metabolic Adaptation to Ingested Material”, PLoS Genetics (2008) Feb 29;4(2): e1000021. PMCID: PMC2265483 
Link to Article

 

M. Hansen, S. Taubert, D. Crawford, N. Libina, S-J. Lee, and C. Kenyon, “Lifespan extension by conditions that inhibit translation in C. elegans”, Aging Cell (2007) 6(1): 95-110.  PMID:17266679.
Link to Article

 

J. Pinkston, D. Garigan, M. Hansen, and C. Kenyon, “Mutations that increase the lifespan of C. elegans inhibit tumor progression”, Science (2006), 313, 971-5. PMID:16917064.
Link to Article 

 

S. Taubert, M. Van Gilst, M. Hansen, and K. Yamamoto, “A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans”, Genes & Development (2006) 20(9):1137-49.  PMCID: PMC1472473.
Link To Article 

 

M. Hansen’, A-L. Hsu’, A. Dillin and C. Kenyon, “New Genes Tied to Endocrine, Metabolic and Dietary Regulation of Longevity in C. elegans”, PLoS Genetics (2005) 1(1): e17 (‘co-first authors). PMCID: PMC1183531.
Link to Article

 

M. Hansen, I. Prior, P. Hughes, B. Oertli, F-L. Chou, B. Willumsen, J. Hancock and M. Ginsberg, “C-terminal sequences in R-Ras are involved in integrin regulation and in plasmamembrane microdomain distribution”. Biochem Biophys Res Comm. (2003) 311 (4): 829-38. PMID:14623256.
Link to Article

 

Kinbara, L. Goldfinger, M. Hansen, F-L. Chou, and Mark Ginsberg, “Ras GTPases: Integrins’ friends or foes?”  Nature Rev Mol Cell Biol, (2003) (10):767-76. Review. PMID:14570053.
Link to Article


 

M. Hansen, E. Rusyn, P. Hughes, M. Ginsberg, A. Cox, and B. Willumsen, “R-Ras sequences are sufficient to confer R-Ras specificity to H-Ras”. Oncogene (2002), 21, 4448-61. PMID:1208047.
Link to Article

 

P. Hughes, B. Oertli, M. Hansen, F-L. Chou, B. Willumsen and M. Ginsberg, “Suppression of integrin activation by activated Ras or Raf does not correlate with Bulk activation of ERK kinase”. Mol Biol Cell. (2002) 7, 2256-65. PMID:12134066.
Link to Article