The Marth Laboratory
Sanford Burnham Prebys Medical Discovery Institute
Infectious and Inflammatory Diseases Center
Research

Autoimmune Diseases

Autoimmune diseases include different syndromes of mostly unknown causes.

Cancer

Cancer treatment is undergoing a biomedical and technological revolution.

Colitis

Intestinal inflammation is the central feature of the Inflammatory Bowel Diseases.

Diabetes

Diabetes is linked to either the failure or destruction of pancreatic beta cells.

Sepsis

Sepsis is an increasingly frequent and lethal syndrome resulting from bloodstream infections.

People

Dr. Jamey Marth, Ph.D.
Professor and Director
Immunity and Pathogeneiss Program
Infectious and Inflammatory Diseases Center
SBP Medical Discovery Institute
jmarth@sbpdiscovery.org

Administrative Personnel

Araceli Ambert
Administrative Assistant
aambert@sbpdiscovery.org

Tja Owens
Administrative Assistant
towens@sbpdiscovery.org

Research Team at Sanford Burnham Prebys and other affiliated Institutes

Peter Aziz, M.Sc.
Research Specialist & Lab Manager
SBP Medical Discovery Institute

Qiongyu Chen
Staff Research Associate
UC San Diego

Jeffrey Esko, Ph.D.
Co-Director, Glycobiology Research & Training Center
Distinguished Professor, Department of Cellular & Molecular Medicine
UC San Diego

Jeffrey Fried, M.D.
Acute Care Physician
Associate Program Director of the Internal Medicine Residency
Director of Critical Care Education and Research
Cottage Hospital Santa Barbara

Vishrut Gupta, B.Sc.
Research Technician
SBP Medical Discovery Institute

Gregory Golden, B.Sc.
Graduate Student
UC San Diego

Douglas Heithoff, Ph.D.
Project Scientist
UC Santa Barbara

John Hintze, Ph.D.
Postdocotral Research Scientist
SBP Medical Discovery Institute

Dzung Le, M.D., Ph.D.
Clinical Professor and Director
UC San Diego

Michael J. Mahan, Ph.D.
Professor
Molecular, Cellular, and Developmental Biology
UC Santa Barbara

Angela Meier, M.D., Ph.D.
Assistant Clinical Professor
UC San Diego

Victor Nizet, M.D.
Professor & Vice Chair for Basic Research, Department of Pediatrics, UCSD
Chief, Division of Host-Microbe Systems & Therapeutics
Professor, Skaggs School of Pharmacy & Pharmaceutical Sciences

Damien Restagno, Ph.D.
Postdoctoral Research Scientist
SBP Medical Discovery Institute

Kathryn Smith, B.Sc.
Research Technician
SBP Medical Discovery Institute

Gabriel Wardi, M.D.
Assistant Professor, Emergency Medicine
UC San Diego

Won Ho Yang, Ph.D.
Assistant Professor, Yonsei University
Senior Research Associate
SBP Medical Research Institute

Selected Publications

Yang, W.H., Westman, J.S., Heithoff, D.M., Sperandio, M., Cho, J.W., Mahan, M.J., and Marth, J.D. (2021)

Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food poisoning.

Proc. Natl. Acad. Sci. USA, 118, doi: 10.1073/pnas.2100937118.

Yang, W.H., Heithoff, D.M., Aziz, P.V., Haslund-Gourley, B., Westman, J.S., Narisawa, S., Pinkerton, A.B., Millan, J.L., Nizet, V., Mahan, M.J., and Marth, J.D. (2018).

Accelerated aging and clearance of host anti-inflammatory enzymes by a subset of pathogens fuels sepsis.

Cell Host & Microbe 24, 500-513.

Yang, W.H., Heithoff, D.M., Aziz, P.V., Sperandio, M., Nizet, V., Mahan, M.J., and Marth, J.D. (2017).

Recurrent infection disables host protection against intestinal inflammation.

Science, 358, doi: 10.1126/science.aao5610.

Yang, W.H., Aziz, P.V., Heithoff, D.M., Mahan, M.J., Smith, J.W., and Marth, J.D. (2015).

An intrinsic mechanism of secreted protein aging and turnover.

Proc. Natl. Acad. Sci. USA 112, 13657-13662.

Grewal, P.K., Aziz, P.V., Uchiyama, S., Rubio, G.R., Lardone, R.D., Le, D, Varki, N., Nizet, V., and Marth, J.D. (2013).

Inducing host protection in pneumococcal sepsis by pre-activation of the Ashwell-Morell receptor.

Proc. Natl. Acad. Sci. USA 17, 110, 20218-20223.

Ohtsubo, K., Chen, M.Z., Olefsky, J.M., and Marth, J.D. (2011).

Pathway to diet- and obesity-associated diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport.

Nat. Med., 17, 1067-1075.

Grewal, P.K., Uchiyama, S., Ditto, D., Varki, N., Le, D.T., Nizet, V., and Marth, J.D. (2008).

N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis.

Nat. Med., 14, 648-655.

Green, R.S., Stone, E.L. Tenno, M., Lehtonen, E., Farquhar, M.G., and Marth, J.D. (2007).

N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis.

Immunity 27, 308-320.

Ohtsubo, K., Takamatsu, S., Minowa, M.T., Yoshida, A., Takeuchi, M., and Marth, J.D. (2005).

Dietary and genetic control of glucose transporter-2 glycosylation promotes insulin secretion in suppressing diabetes.

Cell 123, 1307-1321.

Chui, D., Sellakumar, G., Green, R.S., Sutton-Smith, M., McQuistan, T., Marek, K.W., Morris, H.R., Dell, A., and Marth, J.D. (2001).

Genetic re-modeling of protein glycosylation in vivo induces autoimmune disease.

Proc. Natl. Acad. Sci. USA 98, 1142-1147.

Ellies, L.G., Tsuboi, S., Petryniak, B., Lowe, J.B., Fukuda, M., and Marth, J.D. (1998).

Core 2 O-glycan biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation.

Immunity 9, 881-890.

All Marth Lab Publications

Employment

Interested, qualified applicants for Research Technicians, Postdoctoral Associates, and Medical Research positions should email their resumé or Curriculum Vitae including names and contacts for up to three references to Araceli Ambert, aambert@sbpdiscovery.org.

Contacts

The Marth Laboratory is located at

Sanford Burnham Prebys Medical Discovery Institute
10901 N. Torrey Pines Rd.
La Jolla, CA 92037
Building 5
Laboratory Rooms: 5221, 5215, 5254, 5256
Office Rooms: 5248, 5250

Laboratory Phone Number: (858)795-5109
Office Phone Number: (858)795-5110