Autoimmune diseases include different syndromes of mostly unknown causes.
Cancer treatment is undergoing a biomedical and technological revolution.
Intestinal inflammation is the central feature of the Inflammatory Bowel Diseases.
Diabetes is linked to either the failure or destruction of pancreatic beta cells.
Sepsis is an increasingly frequent and lethal syndrome resulting from bloodstream infections.
Dr. Jamey Marth, Ph.D. Professor and DirectorImmunity and Pathogeneiss Program Infectious and Inflammatory Diseases Center SBP Medical
Discovery Institute email@example.com
Araceli Ambert Administrative Assistant firstname.lastname@example.org
Tja Owens Administrative Assistant email@example.com
Peter Aziz, M.Sc. Research Specialist & Lab Manager SBP Medical Discovery Institute
Qiongyu Chen Staff Research Associate UC San Diego
Jeffrey Esko, Ph.D. Co-Director, Glycobiology Research & Training Center Distinguished Professor, Department of Cellular & Molecular Medicine
UC San Diego
Jeffrey Fried, M.D. Acute Care Physician Associate Program Director of the Internal Medicine Residency
Director of Critical Care Education and Research Cottage Hospital Santa Barbara
Vishrut Gupta, B.Sc.Research Technician SBP Medical Discovery Institute
Gregory Golden, B.Sc.Graduate Student UC San Diego
Douglas Heithoff, Ph.D.Project Scientist UC Santa Barbara
John Hintze, Ph.D. Postdocotral Research Scientist SBP Medical Discovery Institute
Dzung Le, M.D., Ph.D.Clinical Professor and Director UC San Diego
Michael J. Mahan, Ph.D.Professor Molecular, Cellular, and Developmental Biology UC Santa Barbara
Angela Meier, M.D., Ph.D.Assistant Clinical Professor UC San Diego
Victor Nizet, M.D.Professor & Vice Chair for Basic Research, Department of Pediatrics, UCSD
Chief, Division of Host-Microbe Systems & Therapeutics Professor, Skaggs School of Pharmacy & Pharmaceutical Sciences
Damien Restagno, Ph.D.Postdoctoral Research Scientist SBP Medical Discovery Institute
Kathryn Smith, B.Sc.Research Technician SBP Medical Discovery Institute
Gabriel Wardi, M.D.Assistant Professor, Emergency Medicine UC San Diego
Won Ho Yang, Ph.D.Assistant Professor, Yonsei University Senior Research Associate SBP Medical Research Institute
Study finds promising therapeutic target for colitis
September 23, 2021
Jamey Marth awarded $13.5 million by NIH to investigate the pathogenesis and treatment of sepsis
SBP scientist helps develop smartphone app for one-hour identification of bacteria
September 20, 2018
Jamey Marth honored for research linking glycans to diabetes, lupus, sepsis
October 10, 2017
Yang, W.H., Westman, J.S., Heithoff, D.M., Sperandio, M., Cho, J.W., Mahan, M.J., and Marth, J.D. (2021)
Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food poisoning.
Proc. Natl. Acad. Sci. USA, 118, doi: 10.1073/pnas.2100937118.
Yang, W.H., Heithoff, D.M., Aziz, P.V., Haslund-Gourley, B., Westman, J.S., Narisawa, S., Pinkerton, A.B., Millan, J.L., Nizet, V., Mahan, M.J., and Marth, J.D. (2018).
Accelerated aging and clearance of host anti-inflammatory enzymes by a subset of pathogens fuels sepsis.
Cell Host & Microbe 24, 500-513.
Yang, W.H., Heithoff, D.M., Aziz, P.V., Sperandio, M., Nizet, V., Mahan, M.J., and Marth, J.D. (2017).
Recurrent infection disables host protection against intestinal inflammation.
Science, 358, doi: 10.1126/science.aao5610.
Yang, W.H., Aziz, P.V., Heithoff, D.M., Mahan, M.J., Smith, J.W., and Marth, J.D. (2015).
An intrinsic mechanism of secreted protein aging and turnover.
Proc. Natl. Acad. Sci. USA 112, 13657-13662.
Grewal, P.K., Aziz, P.V., Uchiyama, S., Rubio, G.R., Lardone, R.D., Le, D, Varki, N., Nizet, V., and Marth, J.D. (2013).
Inducing host protection in pneumococcal sepsis by pre-activation of the Ashwell-Morell receptor.
Proc. Natl. Acad. Sci. USA 17, 110, 20218-20223.
Ohtsubo, K., Chen, M.Z., Olefsky, J.M., and Marth, J.D. (2011).
Pathway to diet- and obesity-associated diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport.
Nat. Med., 17, 1067-1075.
Grewal, P.K., Uchiyama, S., Ditto, D., Varki, N., Le, D.T., Nizet, V., and Marth, J.D. (2008).
N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis.
Nat. Med., 14, 648-655.
Green, R.S., Stone, E.L. Tenno, M., Lehtonen, E., Farquhar, M.G., and Marth, J.D. (2007).
Immunity 27, 308-320.
Ohtsubo, K., Takamatsu, S., Minowa, M.T., Yoshida, A., Takeuchi, M., and Marth, J.D. (2005).
Dietary and genetic control of glucose transporter-2 glycosylation promotes insulin secretion in suppressing diabetes.
Cell 123, 1307-1321.
Chui, D., Sellakumar, G., Green, R.S., Sutton-Smith, M., McQuistan, T., Marek, K.W., Morris, H.R., Dell, A., and Marth, J.D. (2001).
Genetic re-modeling of protein glycosylation in vivo induces autoimmune disease.
Proc. Natl. Acad. Sci. USA 98, 1142-1147.
Ellies, L.G., Tsuboi, S., Petryniak, B., Lowe, J.B., Fukuda, M., and Marth, J.D. (1998).
Core 2 O-glycan biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation.
Immunity 9, 881-890.
All Marth Lab Publications
Interested, qualified applicants for Research Technicians, Postdoctoral Associates, and Medical Research positions should email their resumé or Curriculum Vitae including names and contacts for up to three references to
Araceli Ambert, firstname.lastname@example.org.
The Marth Laboratory is located at
Sanford Burnham Prebys Medical Discovery Institute
10901 N. Torrey Pines Rd.
La Jolla, CA 92037
Laboratory Rooms: 5221, 5215, 5254, 5256
Office Rooms: 5248, 5250
Laboratory Phone Number: (858)795-5109
Office Phone Number: (858)795-5110