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The Kaufman Lab
Sanford Burnham Prebys Medical Discovery Institute
Neuroscience and Aging Research Center
Research
Lab Members
kaufman lab
Publications

Yong, J., Parekh, V.S., Reilly, S.M., Nayak, J., Chen, Z., Lebeaupin, C., Jang, I., Zhang, J., Prakash, T.P., Sun, H., Murray, S., Guo, S., Ayala, J.A., Satin, L.S., Saltiel, A.R., Kaufman, R.J. (2021) Chop/Ddit3 depletion in β-cells alleviates ER stress and corrects hepatic steatosis. Science Translational Medicine (In Press: Abstract; Full Text).

Hetz, C., Zhang, K., Kaufman, R.J. (2020) Mechanisms, regulation and functions of the unfolded protein response Nat. Rev. Mol. Cell Biol. 21(8):421-438. PMID: 32457508.

Yong, J., Johnson, J.D., Arvan, P., Han, J., Kaufman, R.J. (2021) Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus Nature Reviews Endocrinology.
Jun 23. doi: 10.1038/s41574-021-00510-4. PMID: 34163039 (Cover issue).

Poothong, J.*, Pottekat, A.*, Siirin, M., Campos, A.R., Paton, A.W., Paton, J.C., LagunasAcosta, J., Chen, Z., Swift, M., Volkmann, N., Hanein, D., Yong, J., Kaufman, R.J. (2020) Clotting factor VIII exhibits reversible chaperone-dependent and glucose-regulated amyloid formation in the endoplasmic reticulum. Blood 135:1899-1911. PMC7243144. * Co-first authors. Commentary Blood 135:1825-1827.

353. Sun, J., Xiong, Y., Li, X., Haataja, L., Chen, W., Mir, S.A., Lv, L., Madley, R., Larkin,D., Anjum, A., Dhayalan, B., Rege, N., Wickramasinghe, N.D., Weiss, M.A., Itkin-Ansari, P., Kaufman, R.J., Ostrov, D.A., Arvan, P.*, Liu, M.* (2020) Role of Proinsulin Self-Association in Mutant INS gene-induced Diabetes of Youth. Diabetes 69(5):954-964. *Co-corresponding authors. PMC7171958. Commentary Diabetes 69:802

Tran, D.T., Pottekat, A., Mir, S.A., Jang, I., Loguercio, S., Campos, A.R., Scully, K., Lahmy, R., Liu, M., Arvan, P., Balch, W.E., Kaufman, R.J.*, Itkin-Ansari, P.* (2020) Unbiased profiling of the human proinsulin biosynthetic interaction network reveals a role for peroxiredoxin 4 in proinsulin folding. Diabetes 69(8):1723-1734. * Co-corresponding authors. PMID: 32457219. PMC7372081.

Dasgupta, D., Mauer, A.S., Thompson, J.M., Nakao, Y., Sehrawat, T., Liao, C-Y., Krishnan, A., Lucien, F., Guo, Q., Liu, M., Xue, F., Fukushima, M., Katsumi, T., Bansal, A., Pandey, M.K., Maiers, J.L., DeGrado, T., Pavelko, K.D., Revzin, A., Ibrahim, S.H., Barry, M.A., Kaufman, R.J., Malhi, H. (2020) IRE1α-stimulated hepatocyte-derived extracellular vesicles are proinflammatory in murine nonalcoholic steatohepatitis. Gastroenterology 159(4):1487-1503. PMID: 32574624.

Arunagiri, A., Haataja, L., Pottekat, A., Pamenan, F., Kim, S., Zeltser, L.M., Paton, A.W., Paton, J.C., Tsai, B., Itkin-Ansari, P., Kaufman, R.J.*, Liu, M., Arvan, P.* (2019) Proinsulin misfolding is an early event in the progression to type 2 diabetes. Elife 8. pii: e44532. PMC6559786. * Co-corresponding authors.

Jang, I., Pottekat, A., Poothong, J., Yong, J., Lagunas-Acosta, J., Charbono, A., Chen, Z., Scheuner, D.L., Liu, M., Itkin-Ansari, P., Arvan, P.*, Kaufman., R.J.* (2019) Protein Disulfide Isomerase A1 (PDIA1/P4HB) is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity. Elife. 8. pii: e44528. PMC6559792. * Co-corresponding authors.

Yong, J., Bischof, H., Siirin, M., Murphy, A., Malli, R., Kaufman, R.J. (2019) Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2+. Elife. 8. pii: e49682. PMC6763289.

Contact

The Kaufman Lab is located at:

Sanford Burnham Prebys Medical Discovery Institute
10901 North Torrey Pines Road
La Jolla, CA 92037

Please direct all lab-related inquiries to Alec Duffey

Please direct all research administrative inquiries to Lindsay Bazett