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JOSÉ LUIS MILLÁN, PH.D.
Professor
Sanford Children's Health Research Center

RESEARCH

Dr. José Luis Millán studies the mechanisms that control normal skeletal mineralization and the pathophysiology of diverse calcification disorders.

Bone Mineralization Disorders and Vascular Calcification

Dr. Millán works on understanding the mechanisms that control normal skeletal and dental mineralization and elucidating the pathophysiological abnormalities that lead to soft bone disease states such as hypophosphatasia and ectopic calcification disorders, particularly arterial calcification. Dr. Millán uses the power of mouse genetics to understand the interplay between tissue-nonspecific alkaline phosphatase (TNAP), ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and PHOSPHO1 - three phosphatases that control the phosphate to pyrophosphate ratio optimal to initiate and propagate mineralization of dental and skeletal tissues. His studies have contributed to the pre-clinical validation of a first-in-class treatment for hypophosphatasia, approved in Japan, Europe, Canada and the USA in 2015 for the treatment of pediatric-onset hypophosphatasia. Dr. Millán has also developed small molecules inhibitors able to affect vascular calcification in animal models that may prove useful to treat arterial calcification in a variety of rare and common afflictions.

LAB MEMBERS

Meet the Millán Laboratory

PUBLICATIONS

To access a full listing of Dr. Millán's publications on PubMed, please click here.

 Contact

JOSÉ LUIS MILLÁN, PH.D.
Professor
Sanford Children's Health Research Center

858.646.3130 (phone)
858.795.5381 (fax)
millan@SBPdiscovery.org

Assistant:
AMY ZIMMON
Research Administrative Specialist
858.646.3100 Ext. 3952 (phone)
858.795.5381 (fax)
azimmon@SBPdiscovery.org 

If you are interested in a position in the Millán Lab, please contact Dr. Millán or his assistant Amy Zimmon for information about possible openings.

If you are interested in supporting Dr. Millán's work with a gift, please contact giving@sanfordburnham.org, and you will be contacted by our External Relations Coordinator shortly thereafter.