JOSÉ LUIS MILLÁN, PH.D.
Dr. José Luis Millán studies the mechanisms that control normal skeletal mineralization and the pathophysiology of diverse calcification disorders.
Bone Mineralization Disorders and Vascular Calcification
Dr. Millán works on understanding the mechanisms that control normal skeletal and dental mineralization and elucidating the pathophysiological abnormalities that lead to soft bone disease states such as hypophosphatasia and ectopic calcification disorders, particularly arterial calcification. Dr. Millán uses the power of mouse genetics to understand the interplay between tissue-nonspecific alkaline phosphatase (TNAP), ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and PHOSPHO1 - three phosphatases that control the phosphate to pyrophosphate ratio optimal to initiate and propagate mineralization of dental and skeletal tissues. His studies have contributed to the pre-clinical validation of a first-in-class treatment for hypophosphatasia, approved in Japan, Europe, Canada and the USA in 2015 for the treatment of pediatric-onset hypophosphatasia. Dr. Millán has also developed small molecules inhibitors able to affect vascular calcification in animal models that may prove useful to treat arterial calcification in a variety of rare and common afflictions.
Meet the Millán Laboratory
To access a full listing of Dr. Millán's publications on PubMed, please click here.